Palladium-Catalyzed Stereoselective Construction of 1,3-Stereocenters Displaying Axial and Central Chirality via Asymmetric Alkylations
The concurrent construction of 1,3-stereocenters remains a challenge.Herein, we report the development of stereoselective union of a point chiral center with allenyl Wooden Toy axial chirality in 1,3-position by Pd-catalyzed asymmetric allenylic alkylation between racemic allenyl little boys shorts carbonates and indanone-derived β-ketoesters.Vari